Yes, I use Split mode with my Rev2 all the time.
You will want to turn on Multimode in the global settings. The left side Layer A will be the lower channel, then the Layer B right side will be the next consecutive channel. I use channel 2 and 3.
To determine the split is very easy. Simply hold the Split button and press the keyboard where you want the split to occur. Unfortunately this is not saved per program. If you send a program change to the Rev2 from an external source, it will not remember if that program was in split or layer mode.
The other thing that can get very confusing is the Program #. For example, if you were on Bank U1 P11, then sent a program change to go to P29, the display will still show P11, but the Rev2 will switch to P29, provided you sent the Program Change on the proper channels. In other words, the Rev2 display will not always correspond to the actual program #. This can get very confusing and result in overwriting the wrong program when you make changes then save.
HTH