Just to leave this comment here, in case people find this via search: In the KnobKraft Orm, support for most synths is implemented as a little Python script for each synth. For this, the main software needs to use a Python installation. On Windows, I can ship Python in a matching version together with my application, but for macOS, this is way more complex and I rely on the fact that there is a correct Python version already installed on the mac.
Up until KnobKraft Orm version 1.13.x, I used Python 3.8. But there are no longer installers for macOS Python 3.8 on the python.org website, because it is quite dusted, so from version KnobKraft Orm 1.14 on, the Mac requires a Python 3.10 installation. It can easily be downloaded and installed from Python.org. Always watch out for warnings and errors in the log view of the KnobKraft software, it might give you hints on what is going wrong.
To give you an idea how fun that is for a software developer - the update to Python 3.10 broke support for older Windows 7 machines, which would no longer launch the software. So for Windows, I reverted back to Python 3.8.
Yes, I know, I could have used the Lua programming language instead of Python to avoid these problems, but I do like Python ;-)
(and Dr. Sax and I were able to resolve the issues with a subsequent update, just not here in this forum).