Send midi notes from Studio One through USB sound card does not trigger sound

Setup is the following: DAW; Studio one, running on MacBook Pro. Audio interface: Presonus USB connected to the mac as sound interface.
Rev2 is connected with both audio and mid into the sound card.

I can send midi notes and also audio from REV2 into the DAW, no issue.
But upon sending midi notes from DAW into REV2 I either hear no audio, or hear a triggered (preset?) melody which has nothing to do with mine.
My goal is that DAW sends the midi notes to REV2 and enetually REV2 instrument plays it. It shouldn't be a big deal. 

I did changed midi to slave mode in REV2, I also used user preset and deleted the preconfigured melody on both Layer A and B, still nothing.

Any advise is appreciated