Hi Joe. If your OB-6 Module is brand new, it does require a little of time bit to fill in calibration data across a wide range of operating temperatures. The general rule is that if the oscillators are not in tune from voice to voice, run calibration. If they are in tune directly after calibrating, everything is probably just fine.
The best way to test the voice to voice tuning is by initiating the Basic Program, which is a single oscillator sound with no modulation applied, and pressing the same key six consecutive times. To initiate the Basic Program, hold MANUAL and press WRITE.
If you feel that something else might be going on, please contact our dedicated support channel, which you can do though the Contact Us link on our website, or by emailing support at davesmithinstruments dot com.